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DNA duplexes stabilized by modified monomer residues: synthesis and stability

Graham, Duncan and Parkinson, John A. and Brown, Tom (1998) DNA duplexes stabilized by modified monomer residues: synthesis and stability. Journal of the Chemical Society, Perkin Transactions 1, 1998 (6). pp. 1131-1138. ISSN 1472-7781

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The synthesis of a series of 2'-deoxyuridine analogues modified at the 5-position and a series of 2'-deoxypurines modified at the 8-position is described. Ultraviolet melting studies have been used to assess the stability of DNA duplexes 12- and 8-residues in length that contain these modifications. Of those modified residues which have been incorporated into oligonucleotides, 5-(prop-1-ynyl)-2'-deoxyuridine is found to impart the greatest increase in stability on the DNA duplexes studied.