Prevalence and associated factors for purchasing of antibiotics without a prescription among patients in rural South Africa : implications for addressing antimicrobial resistance

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Maluleke, Tiyani Milta and Maluleke, Morgan Tiyiselani and Ramdas, Nishana and Jelić, Ana Golić and Kurdi, Amanj and Chigome, Audrey and Campbell, Stephen M. and Marković-Peković, Vanda and Schellack, Natalie and Godman, Brian and Meyer, Johanna C. (2025) Prevalence and associated factors for purchasing of antibiotics without a prescription among patients in rural South Africa : implications for addressing antimicrobial resistance. Antibiotics, 14 (12). 1273. ISSN 2079-6382 (https://doi.org/10.3390/antibiotics14121273)

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Abstract

Background: Antimicrobial resistance (AMR) is now a critical issue in South Africa, enhanced by considerable inappropriate prescribing of antibiotics. There is currently variable dispensing of antibiotics without a prescription. Where this occurs, it is principally for urinary tract infections (UTIs) and sexually transmitted infections (STIs). Consequently, there is a need to comprehensively evaluate antibiotic dispensing patterns and factors influencing this to reduce AMR. Methods: A previously piloted questionnaire was administered to patients exiting three different categories of community pharmacies in a rural province. The questionnaire included data on the prevalence of antibiotics dispensed, whether without a prescription, and the rationale for this. Results: A total of 465 patients leaving community pharmacies with a medicine were interviewed. 54.4% of interviewed patients were dispensed at least one antibiotic, with 78.7% dispensed these without a prescription from either independent or franchise pharmacies. Metronidazole (36.1%) and azithromycin (32.7%) were the most dispensed antibiotics. STIs were the most common infectious disease for which an antibiotic was dispensed (60.1%), with 99.6% dispensed without a prescription. Upper respiratory tract infections (URTIs) were the most common infection where antibiotics were dispensed with a prescription (60.0%), with little dispensing without a prescription (7.1%). The most frequently cited reasons for obtaining antibiotics without a prescription were prior use (56.8%), long waiting times at PHC clinics (15.6%), and financial constraints (6.0%). Conclusions: There is an urgent need to review community pharmacists’ scope of practice, including allowing them to prescribe antibiotics for infectious diseases such as UTIs, similar to other countries. Concomitantly, utilise trained community pharmacists to engage with prescribers to improve future antibiotic use, especially for URTIs.

ORCID iDs

Maluleke, Tiyani Milta, Maluleke, Morgan Tiyiselani, Ramdas, Nishana, Jelić, Ana Golić, Kurdi, Amanj ORCID logoORCID: https://orcid.org/0000-0001-5036-1988, Chigome, Audrey, Campbell, Stephen M., Marković-Peković, Vanda, Schellack, Natalie, Godman, Brian and Meyer, Johanna C.;
CORE (COnnecting REpositories)