An insight into real-world practice : what information sources inform the prescribing for children with cancer in Scotland? A focus on emesis, tumour lysis syndrome (TLS), and Pneumocystis Pneumonia (PCP) prophylaxis

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Alkhlaifat, Rahaf and Weir, Natalie M and Mueller, Tanja (2025) An insight into real-world practice : what information sources inform the prescribing for children with cancer in Scotland? A focus on emesis, tumour lysis syndrome (TLS), and Pneumocystis Pneumonia (PCP) prophylaxis. Journal of Oncology Pharmacy Practice. ISSN 1477-092X (https://doi.org/10.1177/10781552251392124)

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Abstract

Within clinical practice, information sources such as clinical guidelines ensure practitioners apply evidence-based information, supporting both effectiveness and safety of the prescribed medicines. Paediatric cancer — a leading cause of death in children — is a complex condition, thus is an area where clinical guidelines are important to give guidance on, e.g., recommended doses, drug dispensing, and toxicity monitoring measures. However, exploring clinical guidelines/information sources and their content regarding medicine-pertaining aspects is rarely done despite the fact they directly inform patient care. This comment summarises the main findings of a document analysis study aimed to describe available documents and their content for Scotland-based paediatric prescribers in oncology wards and provides insights into the documents' comprehensiveness and consistency. The analysis covered three clinical indications which are either highly prevalent or troublesome in practice: emesis, tumour lysis syndrome (TLS), and Pneumocystis Pneumonia (PCP) prophylaxis.

ORCID iDs

Alkhlaifat, Rahaf ORCID logoORCID: https://orcid.org/0000-0002-7007-3534, Weir, Natalie M ORCID logoORCID: https://orcid.org/0000-0003-1422-9415 and Mueller, Tanja ORCID logoORCID: https://orcid.org/0000-0002-0418-4789;
CORE (COnnecting REpositories)