Concentration of secreted frizzled-Related Proteins (SFRPs) in non-small cell lung carcinoma subtypes : a preliminary study

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Gaździcka, Jadwiga and Świętek, Agata and Hudy, Dorota and Dąbrowska, Natalia and Gołąbek, Karolina and Rydel, Mateusz and Czyżewski, Damian and Strzelczyk, Joanna Katarzyna (2023) Concentration of secreted frizzled-Related Proteins (SFRPs) in non-small cell lung carcinoma subtypes : a preliminary study. Current Oncology, 30 (11). pp. 9968-9980. ISSN 1718-7729 (https://doi.org/10.3390/curroncol30110724)

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Abstract

Non-small cell lung carcinoma (NSCLC) is the most common lung cancer worldwide. Secreted frizzled-related proteins (SFRPs) are important tumour suppressors and antagonists of the Wnt signalling pathway, which is linked with cancer development. The aim of this study was to evaluate the concentrations of SFRP1, SFRP2, and SFRP5 proteins in tumour and non-tumour (NT) samples obtained from 65 patients with primary NSCLC. An enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of SFRPs in the tissue homogenates. A significantly lower SFRP2 protein concentration was found in the total NSCLC tumour samples and the following NSCLC subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (AC) (p > 0.05, p = 0.028 and p = 0.001, respectively). AC tumour samples had a higher SFRP1 level than NT samples (p = 0.022), while the highest SFRP1 concentration was found in NSCLC samples from patients with clinical stage T4 cancer. Increased concentrations of SFRP1 and SFRP5 were present in stage III NSCLC samples, while the tumour samples with high pleural invasion (PL2) had an increased level of SFRP2. The results from this study suggest that the tumour suppressor or oncogenic roles of SFRPs could be connected with the NSCLC subtype. The levels of SFRPs varied according to the clinicopathological parameters of NSCLC.

ORCID iDs

Gaździcka, Jadwiga, Świętek, Agata, Hudy, Dorota, Dąbrowska, Natalia ORCID logoORCID: https://orcid.org/0000-0002-5971-5882, Gołąbek, Karolina, Rydel, Mateusz, Czyżewski, Damian and Strzelczyk, Joanna Katarzyna;
CORE (COnnecting REpositories)