Towards electrochemical sensing of gemcitabine release from hybrid nanoparticles in pancreatic cancer cells

Oluwasanmi, Adeolu and Brown, Kelly and Hoskins, Clare and Dennany, Lynn (2025) Towards electrochemical sensing of gemcitabine release from hybrid nanoparticles in pancreatic cancer cells. Sensors and Diagnostics, 4 (11). pp. 966-972. ISSN 2635-0998 (https://doi.org/10.1039/D5SD00110B)

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Abstract

Theranostic clinical translation has been hindered by the lack of analytical tools facilitating interrogation. Here we report the detection of a chemotherapeutic agent, gemcitabine, released via heat trigger, from a hybrid iron oxide–gold theranostic nanoparticle surface in vitro in pancreatic cancer cells by electrochemiluminescence directly addressing this analytical gap.

ORCID iDs

Brown, Kelly ORCID: https://orcid.org/0000-0002-4608-7741

Hoskins, Clare ORCID: https://orcid.org/0000-0002-7200-0566

Dennany, Lynn ORCID: https://orcid.org/0000-0002-5481-1066

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• Item metadata

  Item type:	Article
  ID code:	94106
  Dates:	Date Event 1 November 2025 Published 3 September 2025 Published Online 30 August 2025 Accepted
  Subjects:	Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer) Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	09 Sep 2025 14:39
  Last modified:	21 Jul 2026 05:10
  URI:	https://strathprints.strath.ac.uk/id/eprint/94106