Heavyweight champion : caesium diorganophosphides outperform lighter congeners in the catalytic hydrophosphination of alkenes and alkynes

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Krämer, Felix and Crabbe, Michelle H. and Fernández, Israel and Mulvey, Robert E. (2025) Heavyweight champion : caesium diorganophosphides outperform lighter congeners in the catalytic hydrophosphination of alkenes and alkynes. Angewandte Chemie International Edition, 64 (44). e202516376. ISSN 1521-3773 (https://doi.org/10.1002/anie.202516376)

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Abstract

We present a study of the ability of our recently reported well-defined crown ether-coordinated alkali metal phosphides 1AM to catalyze hydrophosphination (HP) of alkynes and alkenes. In a comparative study including reaction monitoring by 1H NMR spectroscopy, we show that the activity of caesium compound 1Cs greatly exceeds that of its lighter congeners, enabling us to solve some reported challenges of catalytic hydrophosphination. Through the rarely used application of dialkyl phosphines, we were able to produce trialkyl phosphines from HP of styrene derivatives and activated as well as non-activated alkynes by catalytic HP with nBu2PH and tBu2PH. Using tBuPhPH, P-chiral products were obtained, still in racemic mixtures showcasing this system's potential. We also proved the method is suited for preparing unsymmetrical ethylene-bridged bisphosphines by HP of Ph2P(vinyl) isolable in high yields. These advances hint that well-defined organocaesium compounds could make a long-term impact in chemistry.

ORCID iDs

Krämer, Felix, Crabbe, Michelle H., Fernández, Israel and Mulvey, Robert E. ORCID logoORCID: https://orcid.org/0000-0002-1015-2564;
  • Item type:Article
    ID code:94049
    Dates:
    Date
    Event
    27 October 2025
    Published
    10 September 2025
    Published Online
    1 September 2025
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:04 Sep 2025 12:31
    Last modified:13 Aug 2026 12:13
    URI:https://strathprints.strath.ac.uk/id/eprint/94049
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