Role of overnight oximetry in assessing the severity of obstructive sleep apnoea in children with Down syndrome : a dual-centre study

Tools

Vennard, Hannah and Selby, Anna and Ananthamoorthy, Menaga and Buchan, Elise and Burns, Paul and Wilkinson, Thomas L and Lennon, Rebecca and James, Jonathan and Gibson, Neil and Young, David and Samuels, Martin and Evans, Hazel J and Langley, Ross (2025) Role of overnight oximetry in assessing the severity of obstructive sleep apnoea in children with Down syndrome : a dual-centre study. Archives of Disease in Childhood, 111. pp. 27-34. ISSN 0003-9888 (https://doi.org/10.1136/archdischild-2025-328767)

[thumbnail of Vennard-etal-ADC-2025-Role-of-overnight-oximetry-in-assessing-the-severity-of-obstructive-sleep-apnoea]
Preview
 Text. Filename: Vennard-etal-ADC-2025-Role-of-overnight-oximetry-in-assessing-the-severity-of-obstructive-sleep-apnoea.pdf
Accepted Author Manuscript
License: Creative Commons Attribution 4.0 logo
Download (3MB)| Preview

Abstract

Background and objective Cardiorespiratory polygraphy (CRP) is the predominant technology used to diagnose obstructive sleep apnoea (OSA) in tertiary centres in the UK. Nocturnal pulse oximetry (NPO) is cheaper and more accessible. This study evaluates NPO indices’ ability to predict OSA in children with Down syndrome (DS). Methods Indices from simultaneous NPO and CRP recordings were compared in children with DS (aged 2–16 years) referred to evaluate OSA in two tertiary centres across an 8-year period. Receiver operating characteristic curves assessed the diagnostic accuracy of NPO indices, including ODI3 (3% Oxygen Desaturation Index) and ODI4 (4% Oxygen Desaturation Index). Two-by-two tables determined the sensitivities and specificities of cut-off values for predicting OSA. Results 387 children with DS were included with stand-alone NPO; 177 female (46.7%), median age 6.1 years (range 2.02–15.97). There were 265 children (68.5%) with Obstructive Apnoea–Hypopnoea Index (OAHI) ≥1/hour, 164 with OAHI ≥1<5/hour (42.4%), 51 with OAHI ≥5<10/hour (13.2%) and 50 with OAHI ≥10/ hour (12.9%). ODI3 and ODI4 demonstrated the best predictive value for predicting OSA. An ODI3 ≥19/hour and an ODI4 ≥8/hour were associated with the highest combined sensitivity (59.2%/63.8%) and specificity (74.6%/71.3%), respectively. Conclusion Raised ODI3 and ODI4 predict moderate and severe OSA in children with DS with moderate specificity/sensitivity and have a low sensitivity for detecting mild OSA. The poor predictive performance of oximetry reflects the multifactorial nature of sleep disordered breathing in children with DS. We recommend oximetry is not used for diagnosis of OSA in DS and CRP/ polysomnography should be used.

ORCID iDs

Vennard, Hannah, Selby, Anna, Ananthamoorthy, Menaga, Buchan, Elise, Burns, Paul, Wilkinson, Thomas L, Lennon, Rebecca, James, Jonathan, Gibson, Neil, Young, David ORCID logoORCID: https://orcid.org/0000-0002-3652-0513, Samuels, Martin, Evans, Hazel J and Langley, Ross;
CORE (COnnecting REpositories)