Effects of severe acute respiratory syndrome coronavirus 2 strain variation on virus neutralization titers : therapeutic use of convalescent plasma.

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Nguyen, Dung and Xiao, Julie and Simmonds, Peter and Lamikanra, Abigail and Odon, Valerie and Ratcliff, Jeremy and Townsend, Alain and Roberts, David J. and Harvala, Heli (2022) Effects of severe acute respiratory syndrome coronavirus 2 strain variation on virus neutralization titers : therapeutic use of convalescent plasma. Journal of Infectious Diseases, 225 (6). pp. 971-976. ISSN 1537-6613 (https://doi.org/10.1093/infdis/jiab563)

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Abstract

We compared neutralizing antibody titers of convalescent samples collected before and after the emergence of novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), against the wild-type virus and Alpha (B.1.1.7) and Beta (B.1.351) variants. Plasma samples collected in 2020 before emergence of variants showed reduced titers against the Alpha variants, and both sets of samples demonstrated significantly reduced titers against Beta. Comparison of microneutralization titers with those obtained with pseudotype and hemagglutination tests showed a good correlation between their titers and effects of strain variation, supporting the use of these simpler assays for assessing the potency of convalescent plasma against currently circulating and emerging strains of SARS-CoV-2.

ORCID iDs

Nguyen, Dung, Xiao, Julie, Simmonds, Peter, Lamikanra, Abigail, Odon, Valerie ORCID logoORCID: https://orcid.org/0000-0002-2811-6916, Ratcliff, Jeremy, Townsend, Alain, Roberts, David J. and Harvala, Heli;
CORE (COnnecting REpositories)