Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

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Thompson, Craig P and Grayson, Nicholas E and Paton, Robert S and Bolton, Jai S and Lourenço, José and Penman, Bridget S and Lee, Lian N and Odon, Valerie and Mongkolsapaya, Juthathip and Chinnakannan, Senthil and Dejnirattisai, Wanwisa and Edmans, Matthew and Fyfe, Alex and Imlach, Carol and Kooblall, Kreepa and Lim, Nicholas and Liu, Chang and López-Camacho, César and McInally, Carol and McNaughton, Anna L and Ramamurthy, Narayan and Ratcliff, Jeremy and Supasa, Piyada and Sampson, Oliver and Wang, Beibei and Mentzer, Alexander J and Turner, Marc and Semple, Malcolm G and Baillie, Kenneth and Harvala, Heli and Screaton, Gavin R and Temperton, Nigel and Klenerman, Paul and Jarvis, Lisa M and Gupta, Sunetra and Simmonds, Peter, ISARIC4C Investigators (2020) Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. Eurosurveillance, 25 (42). ISSN 1560-7917 (https://doi.org/10.2807/1560-7917.ES.2020.25.42.20...)

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 in Hubei province, China as a cause of respiratory disease occasionally leading to coronavirus disease (COVID-19) [1,2]. Older age, male sex, smoking and comorbidities such as cardiac disease, hypertension and diabetes have been identified as risk factors for severe infections [3,4]. Symptomatic individuals typically exhibit fever, cough and shortness of breath 2–14 days after infection [5]. However, an unknown proportion of individuals experience no symptoms [6-8]. Antibody responses in both symptomatic and asymptomatic individuals are detectable in the blood 14–28 days after infection [9,10]. Subsequently, antibody levels drop and can become undetectable by some antibody assays in the early convalescent phase [9,11,12]. In this study, we used blood donors as a means of estimating population exposure from the start of the pandemic in March through to mid-May when PCR-detected cases in the United Kingdom (UK) had plateaued [13,14]. The detection frequency of neutralising antibodies in blood donors and a discussion of its applicability for estimating population level exposure are presented.

ORCID iDs

Thompson, Craig P, Grayson, Nicholas E, Paton, Robert S, Bolton, Jai S, Lourenço, José, Penman, Bridget S, Lee, Lian N, Odon, Valerie ORCID logoORCID: https://orcid.org/0000-0002-2811-6916, Mongkolsapaya, Juthathip, Chinnakannan, Senthil, Dejnirattisai, Wanwisa, Edmans, Matthew, Fyfe, Alex, Imlach, Carol, Kooblall, Kreepa, Lim, Nicholas, Liu, Chang, López-Camacho, César, McInally, Carol, McNaughton, Anna L, Ramamurthy, Narayan, Ratcliff, Jeremy, Supasa, Piyada, Sampson, Oliver, Wang, Beibei, Mentzer, Alexander J, Turner, Marc, Semple, Malcolm G, Baillie, Kenneth, Harvala, Heli, Screaton, Gavin R, Temperton, Nigel, Klenerman, Paul, Jarvis, Lisa M, Gupta, Sunetra and Simmonds, Peter;
CORE (COnnecting REpositories)