Antifouling peptoid biointerfaces

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Saxena, Varun and Merrilees, Martyn G.L. and Lau, King Hang Aaron; Chandra, Pranjal and Pandey, Lalit, eds. (2020) Antifouling peptoid biointerfaces. In: Biointerface Engineering. Springer Nature, Singapore, pp. 55-73. ISBN 9789811547904 (https://doi.org/10.1007/978-981-15-4790-4_3)

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Abstract

Recent advances in synthetic chemistry has led to the increasingly sophisticated design and preparation of biofunctional polymeric surfaces and materials. In this regard, synthetic poly-(N-substituted glycine) “peptoids” which mimic the structure and function of peptides play an important role since they may attain functionalities similar to natural biopolymers. This chapter reviews efforts by our group and others to develop “antifouling” peptoids—coatings of peptidomimetic polymers that resist the non-specific and undesired adsorption of proteins and attachment of mammalian and microbial cells. We have found that the simplest peptoid—polysarcosine—has been found to be well hydrated and therefore well-suited for antifouling applications. We show that the synthetic convenience of peptoids in general greatly facilitates studies on how polymer chain length, chain density, sidechain chemistry, and specific peptoid sequences may control surface interactions. Indeed, specific peptoids and sequence arrangements have been found to exhibit long-term antifouling properties and excellent resistance against different strains of bacteria. Addition of simple sugar groups to peptoid chains may further enhance resistance against bacteria attachment. Combined with peptoid’s resistance against enzymatic degradation, antifouling peptoids have excellent potential in biomedical applications ranging from coatings of catheters and other biological devices to biosensing and nanomedicine that require a non-fouling interface to achieve improved device performance.

ORCID iDs

Saxena, Varun, Merrilees, Martyn G.L. and Lau, King Hang Aaron ORCID logoORCID: https://orcid.org/0000-0003-3676-9228; Chandra, Pranjal and Pandey, Lalit
  • Item type:Book Section
    ID code:93483
    Dates:
    Date
    Event
    22 July 2020
    Published
    13 June 2019
    Submitted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:14 Jul 2025 12:07
    Last modified:07 Aug 2026 00:53
    URI:https://strathprints.strath.ac.uk/id/eprint/93483
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