Cascading and parallelising curvilinear inertial focusing systems for high volume, wide size distribution, separation and concentration of particles
Miller, B. and Jimenez, M. and Bridle, H. (2016) Cascading and parallelising curvilinear inertial focusing systems for high volume, wide size distribution, separation and concentration of particles. Scientific Reports, 6. 36386. ISSN 2045-2322 (https://doi.org/10.1038/srep36386)
Preview |
Text.
Filename: Miller-etal-SR-2016-Cascading-and-parallelising-curvilinear-inertial-focusing-systems.pdf
Final Published Version License: Download (1MB)| Preview |
Abstract
Inertial focusing is a microfluidic based separation and concentration technology that has expanded rapidly in the last few years. Throughput is high compared to other microfluidic approaches although sample volumes have typically remained in the millilitre range. Here we present a strategy for achieving rapid high volume processing with stacked and cascaded inertial focusing systems, allowing for separation and concentration of particles with a large size range, demonstrated here from 30 μm-300 μm. The system is based on curved channels, in a novel toroidal configuration and a stack of 20 devices has been shown to operate at 1 L/min. Recirculation allows for efficient removal of large particles whereas a cascading strategy enables sequential removal of particles down to a final stage where the target particle size can be concentrated. The demonstration of curved stacked channels operating in a cascaded manner allows for high throughput applications, potentially replacing filtration in applications such as environmental monitoring, industrial cleaning processes, biomedical and bioprocessing and many more.
-
-
Item type: Article ID code: 90126 Dates: DateEvent3 November 2016Published14 October 2016AcceptedSubjects: Medicine > Biomedical engineering. Electronics. Instrumentation Department: Faculty of Science > Mathematics and Statistics
Faculty of Engineering > Biomedical EngineeringDepositing user: Pure Administrator Date deposited: 05 Aug 2024 11:58 Last modified: 05 Aug 2024 11:58 URI: https://strathprints.strath.ac.uk/id/eprint/90126