A monoclinic polymorph of chlorothiazide
Brydson, Rowan K. H. and Kennedy, Alan R. (2024) A monoclinic polymorph of chlorothiazide. Acta Crystallographica Section E: Structure Reports, 80 (Pt 7). pp. 806-810. ISSN 1600-5368 (https://doi.org/10.1107/S2056989024006078)
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Abstract
A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H---O type intermolecular hydrogen bonds as opposed to the N—H---O and N—H---N type hydrogen bonds found in the P1 form.
ORCID iDs
Brydson, Rowan K. H. and Kennedy, Alan R. ORCID: https://orcid.org/0000-0003-3652-6015;-
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Item type: Article ID code: 89765 Dates: DateEventJuly 2024Published28 June 2024Published Online21 June 2024AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 27 Jun 2024 15:34 Last modified: 01 Oct 2024 09:30 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/89765
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