Shaping pancreatic β-cell differentiation and functioning : the influence of mechanotransduction
Galli, Alessandra and Algerta, Marku and Marciani, Paola and Schulte, Carsten and Lenardi, Cristina and Milani, Paolo and Maffioli, Elisa and Tedeschi, Gabriella and Perego, Carla (2020) Shaping pancreatic β-cell differentiation and functioning : the influence of mechanotransduction. Cells, 9 (2). 824. ISSN 2073-4409 (https://doi.org/10.3390/cells9020413)
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Abstract
Embryonic and pluripotent stem cells hold great promise in generating β-cells for both replacing medicine and novel therapeutic discoveries in diabetes mellitus. However, their differentiation in vitro is still inefficient, and functional studies reveal that most of these β-like cells still fail to fully mirror the adult β-cell physiology. For their proper growth and functioning, β-cells require a very specific environment, the islet niche, which provides a myriad of chemical and physical signals. While the nature and effects of chemical stimuli have been widely characterized, less is known about the mechanical signals. We here review the current status of knowledge of biophysical cues provided by the niche where β-cells normally live and differentiate, and we underline the possible machinery designated for mechanotransduction in β-cells. Although the regulatory mechanisms remain poorly understood, the analysis reveals that β-cells are equipped with all mechanosensors and signaling proteins actively involved in mechanotransduction in other cell types, and they respond to mechanical cues by changing their behavior. By engineering microenvironments mirroring the biophysical niche properties it is possible to elucidate the β-cell mechanotransductive-regulatory mechanisms and to harness them for the promotion of β-cell differentiation capacity in vitro.
ORCID iDs
Galli, Alessandra, Algerta, Marku, Marciani, Paola, Schulte, Carsten ORCID: https://orcid.org/0000-0002-7554-5342, Lenardi, Cristina, Milani, Paolo, Maffioli, Elisa, Tedeschi, Gabriella and Perego, Carla;-
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Item type: Article ID code: 89699 Dates: DateEvent11 February 2020Published11 February 2020Published Online7 February 2020AcceptedSubjects: Medicine > Biomedical engineering. Electronics. Instrumentation
Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > PhysiologyDepartment: Faculty of Engineering > Biomedical Engineering Depositing user: Pure Administrator Date deposited: 21 Jun 2024 14:39 Last modified: 03 Oct 2024 10:16 URI: https://strathprints.strath.ac.uk/id/eprint/89699