The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases
Krause, Stefan and Ouellet, Valerie and Allen, Deonie and Allen, Steven and Moss, Kerry and Nel, Holly A. and Manaseki-Holland, Semira and Lynch, Iseult (2024) The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases. Cell Reports Medicine, 5 (6). 101581. ISSN 2666-3791 (https://doi.org/10.1016/j.xcrm.2024.101581)
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Abstract
Non-communicable diseases (NCD) constitute one of the highest burdens of disease globally and are associated with inflammatory responses in target organs. There is increasing evidence of significant human exposure to micro- and nanoplastics (MnPs). This review of environmental MnP exposure and health impacts indicates that MnP particles, directly and indirectly through their leachates, may exacerbate inflammation. Meanwhile, persistent inflammation associated with NCDs in gastrointestinal and respiratory systems potentially increases MnP uptake, thus influencing MnP access to distal organs. Consequently, a future increase in MnP exposure potentially augments the risk and severity of NCDs. There is a critical need for an integrated one-health approach to human health and environmental research for assessing the drivers of human MnP exposure and their bidirectional links with NCDs. Assessing these risks requires interdisciplinary efforts to identify and link drivers of environmental MnP exposure and organismal uptake to studies of impacted disease mechanisms and health outcomes.
ORCID iDs
Krause, Stefan, Ouellet, Valerie, Allen, Deonie ORCID: https://orcid.org/0000-0002-4038-9394, Allen, Steven ORCID: https://orcid.org/0000-0002-2333-6514, Moss, Kerry, Nel, Holly A., Manaseki-Holland, Semira and Lynch, Iseult;-
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Item type: Article ID code: 89632 Dates: DateEvent18 June 2024Published22 May 2024Published Online29 April 2024Accepted11 October 2023SubmittedSubjects: Medicine > Public aspects of medicine Department: Faculty of Engineering > Civil and Environmental Engineering Depositing user: Pure Administrator Date deposited: 17 Jun 2024 16:20 Last modified: 28 Oct 2024 21:15 URI: https://strathprints.strath.ac.uk/id/eprint/89632