Pushing the limits

Wallace, Gregory Q. and Graham, Duncan (2022) Pushing the limits. Nature Reviews Chemistry, 6 (12). pp. 842-843. ISSN 2397-3358 (https://doi.org/10.1038/s41570-022-00444-z)

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Abstract

In 1997, Kneipp et al. and Nie and Emory independently reported the first examples of single-molecule detection using surface-enhanced Raman scattering (SERS). These seminal works sparked a surge of interest in SERS, while introducing a new question: how can it be conclusively proven that just one molecule is being probed?