A study of the reactivity of cyclic aminomethylammonium mannich salts
Dimitrova, Daniela and McMahon, Connor and Kennedy, Alan R. and Parkinson, John A. and Leach, Stuart G. and Boulton, Lee T. and Pascoe, David D. and Murphy, John A. (2022) A study of the reactivity of cyclic aminomethylammonium mannich salts. Tetrahedron, 128. 133120. ISSN 0040-4020 (https://doi.org/10.1016/j.tet.2022.133120)
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Abstract
A novel method for the preparation of aminoalkylaminomethyl products was developed utilising novel Mannich-type salts featuring a R 2NCH 2NR 3 + moiety. This methodology showed good nucleophile scope and was successfully employed in reactions under basic, acidic, and neutral conditions. A wide range of diamine products was successfully synthesised, including a neuropeptide Y antagonist.
ORCID iDs
Dimitrova, Daniela, McMahon, Connor, Kennedy, Alan R. ORCID: https://orcid.org/0000-0003-3652-6015, Parkinson, John A. ORCID: https://orcid.org/0000-0003-4270-6135, Leach, Stuart G., Boulton, Lee T., Pascoe, David D. and Murphy, John A.;-
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Item type: Article ID code: 83293 Dates: DateEvent3 December 2022Published5 November 2022Published Online27 October 2022AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 22 Nov 2022 14:41 Last modified: 03 Oct 2024 00:39 URI: https://strathprints.strath.ac.uk/id/eprint/83293