Catalytic reductive N-alkylation of amines using carboxylic acids

Andrews, Keith G. and Summers, Declan M. and Donnelly, Liam J. and Denton, Ross M. (2016) Catalytic reductive N-alkylation of amines using carboxylic acids. Chemical Communications, 2016 (9). pp. 1855-1858. ISSN 1359-7345 (https://doi.org/10.1039/c5cc08881j)

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Abstract

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.