The application of field-flow fractionation to the analysis of nanomedicines

Daramy, Karim and Punnabhum, Panida and Walker, Joshua and Bindhu Syammohan, Syampriya and Rattray, Zahra (2022) The application of field-flow fractionation to the analysis of nanomedicines. British Journal of Pharmacy, 7 (2). ISSN 2058-8356 (https://doi.org/10.5920/bjpharm.1132)

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Abstract

Thecombination of field-flow fractionation with powerful leading-edge detectors canbe applied to the measurement of nanomaterial physicochemical properties, and thecreation of harmonized robust measurement protocols. The Multiscale MetrologySuite (MMS) at the University of Strathclyde is a unique internationallyleading facility combining multiple leading-edge field flow fractionation modalities(electric, asymmetric and centrifugal) with in-line Raman, inductively-coupledplasma (ICP) mass spectrometry and multimodal detector capability. Using exemplarcase studies, we demonstrate the application of various FFF hyphenations for the analysis of a diverse materials portfolio. One of the goals for the MMS isto raise the standards of traditional academic analytical support underpinningpioneering academic engineering, physical and life sciences research exploringnovel materials as diagnostics and therapeutics.

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