Solid lipid nanoparticles and nanostructured lipid carriers of dual functionality at emulsion interfaces. Part I : Pickering stabilisation functionality
Sakellari, Georgia I. and Zafeiri, Ioanna and Batchelor, Hannah and Spyropoulos, Fotis (2022) Solid lipid nanoparticles and nanostructured lipid carriers of dual functionality at emulsion interfaces. Part I : Pickering stabilisation functionality. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 654. 130135. ISSN 0927-7757 (https://doi.org/10.1016/j.colsurfa.2022.130135)
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Abstract
Solid lipid nanoparticles and nanostructured lipid carriers are two types of lipid nanoparticulate systems, that have been primarily studied for their capability to function as active carriers, and only more recently utilised in Pickering emulsion stabilisation. Unveiling the factors that impact upon the lipid particle characteristics related to their Pickering functionality could enable the development of a liquid formulation with tailored microstructure and potentially the capacity to display a two-fold performance. In part I, this work investigates how certain formulation characteristics, namely solid-to-liquid lipid mass ratio and presence of unadsorbed surfactant in the aqueous carrier phase, affect the structural properties of the lipid particles, and in turn how these influence their Pickering stabilisation capacity. The effect of the formulation parameters was assessed in terms of the wettability and physicochemical properties of the lipid particles, including particle size, crystallinity and interfacial behaviour. Lipid particles fabricated with higher liquid lipid content (70% w/w) were shown to be more hydrophilic and have lower surfactant decoration at their surface compared to particles containing lower or no liquid lipid in their crystalline matrix. The emulsion stabilisation ability through a Pickering mechanism was confirmed for all types of lipid particles using polarised microscopy. Increasing liquid lipid content and removal of excess surfactant did not compromise the particle stabilisation capacity, though emulsion droplets of larger sizes were initially acquired in the latter case. The particle-stabilised emulsions maintained their physical integrity, with particles retaining close association with the emulsion interface over a storage period of 12 weeks.
ORCID iDs
Sakellari, Georgia I., Zafeiri, Ioanna, Batchelor, Hannah ORCID: https://orcid.org/0000-0002-8729-9951 and Spyropoulos, Fotis;-
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Item type: Article ID code: 82648 Dates: DateEvent5 December 2022Published9 September 2022Published Online6 September 2022AcceptedSubjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 11 Oct 2022 08:34 Last modified: 11 Sep 2024 16:40 URI: https://strathprints.strath.ac.uk/id/eprint/82648