A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH : possible association with estrogen metabolism

MacLean, Margaret R. and Pandya, Divya and Swietlik, Emilia M. and Denver, Nina and Mair, Kirsty and Morrell, Nicholas W. and Gräf, Stefan (2022) A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH : possible association with estrogen metabolism. Pulmonary Circulation, 12 (3). e12139. ISSN 2045-8940 (https://doi.org/10.1002/pul2.12139)

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Abstract

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1-pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body-weight in mice and man may be associated with increased estrogen metabolism.

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