A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH : possible association with estrogen metabolism

MacLean, Margaret R. and Pandya, Divya and Swietlik, Emilia M. and Denver, Nina and Mair, Kirsty and Morrell, Nicholas W. and Gräf, Stefan (2022) A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH : possible association with estrogen metabolism. Pulmonary Circulation, 12 (3). e12139. ISSN 2045-8940 (https://doi.org/10.1002/pul2.12139)

[thumbnail of MacLean-etal-PC-2022-A-pilot-study-to-examine-association-of-BMI-with-Functional-class-and-six-minute-walk-distance]
Preview
Text. Filename: MacLean_etal_PC_2022_A_pilot_study_to_examine_association_of_BMI_with_Functional_class_and_six_minute_walk_distance.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (432kB)| Preview

Abstract

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1-pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body-weight in mice and man may be associated with increased estrogen metabolism.