Miniaturized chemical tags for optical imaging

Benson, Sam and de Moliner, Fabio and Tipping, William and Vendrell, Marc (2022) Miniaturized chemical tags for optical imaging. Angewandte Chemie, 134 (34). e202204788. ISSN 0044-8249 (https://doi.org/10.1002/ange.202204788)

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Abstract

Recent advances in optical bioimaging have prompted the need for minimal chemical reporters that can retain the molecular recognition properties and activity profiles of biomolecules. As a result, several methodologies to reduce the size of fluorescent and Raman labels to a few atoms (e.g., single aryl fluorophores, Raman active triple bonds and isotopes) and embed them into building blocks (e.g., amino acids, nucleobases, sugars) to construct native-like supramolecular structures have been described. The integration of small optical reporters into biomolecules has also led to smart molecular entities that were previously inaccessible in an expedite manner. In this article, we review recent chemical approaches to synthesize miniaturized optical tags as well as some of their multiple applications in biological imaging.

  • Item type:Article
    ID code:81392
    Dates:
    Date
    Event
    22 August 2022
    Published
    15 June 2022
    Published Online
    15 June 2022
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:07 Jul 2022 11:43
    Last modified:18 Apr 2024 00:32
    URI:https://strathprints.strath.ac.uk/id/eprint/81392
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