Oral amphotericin B : the journey from bench to market
Serrano, Dolores R. and Lalatsa, Aikaterini (2017) Oral amphotericin B : the journey from bench to market. Journal of Drug Delivery Science and Technology, 42. pp. 75-83. ISSN 1773-2247 (https://doi.org/10.1016/j.jddst.2017.04.017)
Preview |
Text.
Filename: Serrano_Lalatsa_JDDST_2017_Oral_amphotericin_B_the_journey_from_bench.pdf
Accepted Author Manuscript License: Download (479kB)| Preview |
Abstract
Since the 1950s, amphotericin B (AmB) has been used in the clinical practice to treat systemic fungal infections and leishmaniasis, a neglected parasitic disease that can be fatal if left untreated. Fungizone® (a micellar dispersion) was the "gold standard" for more than three decades but due to the safer profile of novel lipid-based medicines (AmBisome®, Abelcet® and Amphocil®), it is now used as second-line in the developed world. Lipid-based medicines possess a more favourable safety profile (mainly lower nephrotoxicity and infusion-related side effects) allowing the administration of larger doses and therefore similar efficacy with fewer administrations. However, all formulations require parenteral administration because AmB has low oral bioavailability (0.2–0.9%) due to the precipitation of drug in aqueous media. In the last decade, strong partnerships between academia and industry has led to the development of innovative drug delivery systems able to deliver and target orally AmB in effective concentrations while reducing its nephrotoxicity and infusion-related side effects. Currently, three major platform technologies (cochleates, chitosan nanoparticles and SEDDS) that are undergoing clinical trials are discussed in this review. The pharmacokinetic and pharmacodynamic profile against visceral leishmaniasis, systemic candidiasis and aspergillosis of novel delivery systems will be discussed.
ORCID iDs
Serrano, Dolores R. and Lalatsa, Aikaterini ORCID: https://orcid.org/0000-0003-4791-7468;-
-
Item type: Article ID code: 80829 Dates: DateEvent31 December 2017Published13 April 2017Published Online10 April 2017AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 19 May 2022 14:13 Last modified: 01 Sep 2024 01:35 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/80829