Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery
Lalatsa, Aikaterini and Patel, Priyanka V. and Sun, Yujiao and Kiun, Chong C. and Karimi, Ferishtah and Zekonyte, Jurgita and Emeriewen, Krisztina and Saleh, George M. (2020) Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery. International Journal of Pharmaceutics, 577. 119003. ISSN 1873-3476 (https://doi.org/10.1016/j.ijpharm.2019.119003)
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Abstract
Local anaesthetics are administered as a diffuse superficial slow injection in blepharoplasty. Current transcutaneous local anaesthetic formulations are not licensed for use on the face due to safety concerns. Here we report for the first time the permeation of local anaesthetics (lidocaine, bupivacaine loaded SNEDDS and their hydrogels) across human eyelid and mouse skin as a novel and ocular safe formulation for eyelid surgery. SNEDDS were loaded with high levels of anaesthetics and incorporated within carbomer hydrogels to yield nano-enabled gels. Lidocaine hydrogels have a significantly reduced lag time compared to EMLA, while they enhance lidocaine flux across human eyelid skin by 5.2 fold. Ex vivo tape stripping experiments indicated localisation of anaesthetics within the stratum corneum and dermis. Initial histopathological studies have shown no apparent signs of skin irritation. These results highlight the potential clinical capability of nano-enabled anaesthetic hydrogels as a non-invasive anaesthetic procedure for eyelid surgery.
ORCID iDs
Lalatsa, Aikaterini ORCID: https://orcid.org/0000-0003-4791-7468, Patel, Priyanka V., Sun, Yujiao, Kiun, Chong C., Karimi, Ferishtah, Zekonyte, Jurgita, Emeriewen, Krisztina and Saleh, George M.;-
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Item type: Article ID code: 80789 Dates: DateEvent15 March 2020Published24 January 2020Published Online26 December 2019AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 18 May 2022 11:10 Last modified: 04 Oct 2024 00:38 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/80789