Engineering 3D printed microfluidic chips for the fabrication of nanomedicines
Kara, Aytug and Vassiliadou, Athina and Ongoren, Baris and Keeble, William and Hing, Richard and Lalatsa, Aikaterini and Serrano, Dolores R. (2021) Engineering 3D printed microfluidic chips for the fabrication of nanomedicines. Pharmaceutics, 13 (12). 2134. ISSN 1999-4923 (https://doi.org/10.3390/pharmaceutics13122134)
Preview |
Text.
Filename: Kara_etal_Pharmaceutics_2021_Engineering_3D_printed_microfluidic_chips_for_the_fabrication.pdf
Final Published Version License: Download (3MB)| Preview |
Abstract
Currently, there is an unmet need to manufacture nanomedicines in a continuous and controlled manner. Three-dimensional (3D) printed microfluidic chips are an alternative to conventional PDMS chips as they can be easily designed and manufactured to allow for customized designs that are able to reproducibly manufacture nanomedicines at an affordable cost. The manufacturing of microfluidic chips using existing 3D printing technologies remains very challenging because of the intricate geometry of the channels. Here, we demonstrate the manufacture and characterization of nifedipine (NFD) polymeric nanoparticles based on Eudragit L-100 using 3D printed microfluidic chips with 1 mm diameter channels produced with two 3D printing techniques that are widely available, stereolithography (SLA) and fuse deposition modeling (FDM). Fabricated polymeric nanoparticles showed good encapsulation efficiencies and particle sizes in the range of 50–100 nm. SLA chips possessed better channel resolution and smoother channel surfaces, leading to smaller particle sizes similar to those obtained by conventional manufacturing methods based on solvent evaporation, while SLA manufactured nanoparticles showed a minimal burst effect in acid media compared to nanoparticles fabricated with FDM chips. Three-dimensional printed microfluidic chips are a novel and easily amenable cost-effective strategy to allow for customization of the design process for continuous manufacture of nanomedicines under controlled conditions, enabling easy scale-up and reducing nanomedicine development times, while maintaining high-quality standards.
ORCID iDs
Kara, Aytug, Vassiliadou, Athina, Ongoren, Baris, Keeble, William, Hing, Richard, Lalatsa, Aikaterini ORCID: https://orcid.org/0000-0003-4791-7468 and Serrano, Dolores R.;-
-
Item type: Article ID code: 80677 Dates: DateEvent10 December 2021Published7 December 2021AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 12 May 2022 11:38 Last modified: 15 Sep 2024 09:41 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/80677