Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research

Senekowitsch, Stefan and Schick, Philipp and Abrahamsson, Bertil and Augustijns, Patrick and Gießmann, Thomas and Lennernäs, Hans and Matthys, Christophe and Marciani, Luca and Pepin, Xavier and Perkins, Alan and Feldmüller, Maximilian and Sulaiman, Sarah and Weitschies, Werner and Wilson, Clive G. and Corsetti, Maura and Koziolek, Mirko (2022) Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14 (4). 801. ISSN 1999-4923 (https://doi.org/10.3390/pharmaceutics14040801)

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Abstract

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Understanding Gastrointestinal Absorption-related Processes (UNGAP)” was initiated in 2017, with the aim to improve the current comprehension of intestinal drug absorption and foster future developments in this field. In this regard, in vivo techniques used for the characterization of human GI physiology and the intraluminal behavior of orally administered dosage forms in the GI tract are fundamental to gaining deeper mechanistic understanding of the interplay between human GI physiology and drug product performance. In this review, the potential applications, advantages, and limitations of the most important in vivo techniques relevant to oral biopharmaceutics are presented from the perspectives of different research fields.

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