Overcoming drug resistance, the natural way

Hutchings, Matthew I. and Duncan, Katherine R. (2022) Overcoming drug resistance, the natural way. Cell Host & Microbe, 30 (3). pp. 273-274. ISSN 1931-3128 (https://doi.org/10.1016/j.chom.2022.02.008)

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Abstract

Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to identify and synthesize a natural variant that bypasses colistin resistance and offers new hope for tackling antimicrobial resistance.