The selfish mitochondrion
McCarron, John G. and Wilson, Calum (2021) The selfish mitochondrion. Cell Calcium, 100. 102498. ISSN 0143-4160 (https://doi.org/10.1016/j.ceca.2021.102498)
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Abstract
Mitochondria match ATP supply to fluctuations in cellular energy requirements. Cellular energy requirements are often signaled to mitochondria by increases in the cytoplasmic concentration of Ca2+ ions. These increases in Ca2+ reach the mitochondrial matrix to regulate the proteins, enzymes and transporters required for mitochondrial ATP synthesis. Mitochondria may also limit energy demands by capturing the ion and shaping cytosolic Ca2+ signaling. Mitochondrial uptake of Ca2+ is driven by the substantial electrochemical gradient generated by the respiratory chain complexes. Although functional studies since the 1960s hinted at the nature of the Ca2+ channel involved, the molecular identity eluded physiologists until 2011 when the mitochondrial Ca2+ uniporter (MCU) gene was identified. MCU is a Ca2+-selective inwardly rectifying channel and a major pathway for the passage of Ca2+ ions from the cytoplasm into mitochondria. However, while well understood at the genetic and protein level, how MCU regulates cell function is unresolved. Understanding MCU regulation is of the utmost importance as disturbances in mitochondrial Ca2+ uptake accompanies several human diseases.
ORCID iDs
McCarron, John G. ORCID: https://orcid.org/0000-0002-3302-3984 and Wilson, Calum ORCID: https://orcid.org/0000-0003-2500-0632;-
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Item type: Article ID code: 78452 Dates: DateEvent31 December 2021Published8 November 2021Published Online4 November 2021AcceptedSubjects: Science Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 08 Nov 2021 13:55 Last modified: 04 Oct 2024 00:37 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/78452