Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases

Paraskevaidi, Maria and Baker, Matthew J. and Butler, Holly J. and Hugh, Byrne J. and Thulya, Chakkumpulakkal P. V. and Loren, Christie and StJohn, Crean and Peter, Gardner and Callum, Gassner and Sergei, Kazarian G. and Kamila, Kochan and Maria, Kyrgiou and Kássio, Lima M. G. and Pierre, Martin-Hirsch L. and Evangelos, Paraskevaidis and Savithri, Pebotuwa and John, Adegoke A. and Alexandra, Sala and Marfran, Santos and Josep, Sulé-Suso and Gunjan, Tyagi and Michael, Walsh and Bayden, Wood (2021) Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases. Applied Spectroscopy Reviews, 56 (8-10). pp. 804-868. ISSN 1520-569X (https://doi.org/10.1080/05704928.2021.1946076)

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Abstract

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the need for multiple tests before a definitive diagnosis. Spectroscopic techniques, including infrared (IR) and Raman, have attracted great interest in the medical field, with applications expanding from early disease detection to monitoring and real-time diagnosis. This review highlights applications of IR and Raman spectroscopy, with a focus on cancer and infectious diseases since 2015, and underscores the diverse sample types that can be analyzed, such as biofluids, cells and tissues. Studies involving more than 25 participants per group (disease and control group; if no control group >25 in disease group) were considered eligible, to retain the clinical focus of the paper. Following literature searches, we identified 94 spectroscopic studies on different cancers and 30 studies on infectious diseases. The review suggests that such technologies have the potential to develop into an objective, inexpensive, point-of-care test or facilitate disease diagnosis and monitoring. Up-to-date considerations for the implementation of spectroscopic techniques into a clinical setting, health economics and successful applications of vibrational spectroscopic tests in the clinical arena are also discussed.

  • Item type:Article
    ID code:78200
    Dates:
    Date
    Event
    26 November 2021
    Published
    6 October 2021
    Published Online
    6 September 2021
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:19 Oct 2021 10:19
    Last modified:09 Apr 2024 02:47
    URI:https://strathprints.strath.ac.uk/id/eprint/78200
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