Ins(1,4,5)P3 receptor regulation during ‘quantal’ Ca2+ release in smooth muscle
McCarron, J.G. and Olson, M. and Rainbow, R. and MacMillan, D. and Chalmers, S. (2007) Ins(1,4,5)P3 receptor regulation during ‘quantal’ Ca2+ release in smooth muscle. Trends in Pharmacological Sciences, 28 (6). pp. 271-279. ISSN 0165-6147 (http://dx.doi.org/10.1016/j.tips.2007.04.007)
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Smooth muscle is activated by plasma-membrane-acting agonists that induce inositol (1,4,5)-trisphosphate [Ins(1,4,5)P3] to release Ca2+ from the intracellular sarcoplasmic reticulum (SR) Ca2+ store. Increased concentrations of agonist evoke a concentration-dependent graded release of Ca2+ in a process called ‘quantal’ Ca2+ release. Such a graded release seems to be incompatible with both the finite capacity of the SR store and the positive-feedback Ca2+-induced Ca2+ release (CICR)-like process that is operative at Ins(1,4,5)P3 receptors, which – once activated – might be expected to deplete the entire store. Proposed explanations of quantal release include the existence of multiple stores, each with different sensitivities to Ins(1,4,5)P3, or Ins(1,4,5)P3 receptor opening being controlled by the Ca2+ concentration within the SR. Here, we suggest that the regulation of Ins(1,4,5)P3 receptors by the Ca2+ concentration within the SR explains the quantal Ca2+-release process and the apparent existence of multiple Ca2+ stores in smooth muscle.
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Item type: Article ID code: 7637 Dates: DateEvent2007PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Strathprints Administrator Date deposited: 06 Mar 2009 15:49 Last modified: 08 Apr 2024 16:10 URI: https://strathprints.strath.ac.uk/id/eprint/7637