In-hospital mortality in SARS-CoV-2 stratified by hemoglobin levels : a retrospective study

Al-Jarallah, Mohammed and Rajan, Rajesh and Al Saber, Ahmad and Pan, Jiazhu and T.Al-Sultan, Ahmad and Abdelnaby, Hassan and Alroomi, Moudhi and Dashti, Raja and Aboelhassan, Wael and Almutairi, Farah and Abdullah, Mohammed and Alotaibi, Naser and Al Saleh, Mohammad and AlNasrallah, Noor and Al-Bader, Bader and Malhas, Haya and Ramadhan, Maryam and Hamza, Mahdy and Zhanna, Kobalava D. (2021) In-hospital mortality in SARS-CoV-2 stratified by hemoglobin levels : a retrospective study. eJHaem, 2 (3). 335–339. ISSN 2688-6146 (

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This study is to estimate in-hospital mortality in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients stratified by hemoglobin (Hb) level. Patients were stratified according to hemoglobin level into two groups, that is, Hb <100 g/L and Hb >100 g/L. A total of 6931 patients were included. Of these, 6377 (92%) patients had hemoglobin levels >100 g/L. The mean age was 44 ± 17 years, and 66% of the patients were males. The median length of overall hospital stay was 13 days [2; 31]. The remaining 554 (8%) patients had a hemoglobin level <100 g/L. Overall mortality was 176 patients (2.54%) but was significantly higher in the group with hemoglobin levels <100 g/L (124, 22.4%) than in the group with hemoglobin levels >100 g/L (52, 0.82%). Risk factors associated with increased mortality were determined by multi- variate analysis. The Kaplan-Meier survival analysis showed hemoglobin as a predictor of mortality. Cox proportional hazards regression coefficients for hemoglobin for the HB ≤ 100 category of hemoglobin were significant, B = 2.79, SE = 0.17, and HR = 16.34, p < 0.001. Multivariate logistic regression showed Hb < 100 g/L had a higher cumu- lative all-cause in-hospital mortality (22.4% vs. 0.8%; adjusted odds ratio [aOR], 0.33; 95% [CI]: [0.20–0.55]; p < 0.001). In this study, hemoglobin levels <100 g/L were found to be an independent predictor of in-hospital mortality.


Al-Jarallah, Mohammed, Rajan, Rajesh, Al Saber, Ahmad ORCID logoORCID:, Pan, Jiazhu ORCID logoORCID:, T.Al-Sultan, Ahmad, Abdelnaby, Hassan, Alroomi, Moudhi, Dashti, Raja, Aboelhassan, Wael, Almutairi, Farah, Abdullah, Mohammed, Alotaibi, Naser, Al Saleh, Mohammad, AlNasrallah, Noor, Al-Bader, Bader, Malhas, Haya, Ramadhan, Maryam, Hamza, Mahdy and Zhanna, Kobalava D.;