Photoactivated release of membrane impermeant sulfonates inside cells

Caldwell, Stuart T. and O’Byrne, Sean N. and Wilson, Calum and Cvetko, Filip and Murphy, Michael P. and McCarron, John G. and Hartley, Richard C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57 (32). pp. 3917-3920. ISSN 1359-7345 (https://doi.org/10.1039/D0CC07713E)

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Abstract

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

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• Item metadata

  Item type:	Article
  ID code:	75742
  Dates:	Date Event 25 April 2021 Published 12 March 2021 Published Online 9 March 2021 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	09 Mar 2021 16:55
  Last modified:	09 Aug 2024 01:16
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/75742