Photoactivated release of membrane impermeant sulfonates inside cells

Caldwell, Stuart T. and O’Byrne, Sean N. and Wilson, Calum and Cvetko, Filip and Murphy, Michael P. and McCarron, John G. and Hartley, Richard C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57 (32). pp. 3917-3920. ISSN 1359-7345 (

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Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.


Caldwell, Stuart T., O’Byrne, Sean N., Wilson, Calum ORCID logoORCID:, Cvetko, Filip, Murphy, Michael P., McCarron, John G. ORCID logoORCID: and Hartley, Richard C.;