Sex differences in pulmonary hypertension

Morris, Hannah and Denver, Nina and Gaw, Rosemary and Labazi, Hicham and Mair, Kirsty and MacLean, Margaret R. (2021) Sex differences in pulmonary hypertension. Clinics in Chest Medicine, 42 (1). pp. 217-228. ISSN 1557-8216

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    Abstract

    Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.