Liposomes : advancements and innovation in the manufacturing process
Shah, Sanket and Dhawan, Vivek and Holm, René and Nagarsenker, Mangal S. and Perrie, Yvonne (2020) Liposomes : advancements and innovation in the manufacturing process. Advanced Drug Delivery Reviews, 154-155. pp. 102-122. ISSN 0169-409X (https://doi.org/10.1016/j.addr.2020.07.002)
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Abstract
Liposomes are well recognised as effective drug delivery systems, with a range of products approved, including follow on generic products. Current manufacturing processes used to produce liposomes are generally complex multi-batch processes. Furthermore, liposome preparation processes adopted in the laboratory setting do not offer easy translation to large scale production, which may delay the development and adoption of new liposomal systems. To promote advancement and innovation in liposome manufacturing processes, this review considers the range of manufacturing processes available for liposomes, from laboratory scale and scale up, through to large-scale manufacture and evaluates their advantages and limitations. The regulatory considerations associated with the manufacture of liposomes is also discussed. New innovations that support leaner scalable technologies for liposome fabrication are outlined including self-assembling liposome systems and microfluidic production. The critical process attributes that impact on the liposome product attributes are outlined to support potential wider adoption of these innovations.
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Item type: Article ID code: 75205 Dates: DateEvent8 July 2020Published2 January 2020AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 28 Jan 2021 10:28 Last modified: 11 Dec 2024 15:52 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/75205