Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies

Pereira-Silva, Miguel and Santos, Ana Cláudia and Conde, João and Hoskins, Clare and Concheiro, Angel and Alvarez-Lorenzo, Carmen and Veiga, Francisco (2020) Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies. Expert Opinion on Drug Delivery. ISSN 1742-5247

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    Abstract

    Cancer ranks amongst the most deadliest diseases, associated with significant burden, often fatal prognosis and huge clinical challenge [1]. Cancer management has substantially improved mainly on cancer diagnostics and therapeutics, resulting in extended survival rates and decreased mortality worldwide. Chemotherapy, along with radiotherapy and surgery, represents one of the major therapeutic approaches for cancer cells eradication, however associated with several shortcomings, as poor cancer tissue biodistribution, accelerated drug degradation and clearance, insufficient cancer targetability and still high systemic toxicity, overall compromising efficacy and safety [2, 3].