Revisiting criteria for psychosis in Alzheimer's disease and related dementias : toward better phenotypic classification and biomarker research

Fischer, Corinne E. and Ismail, Zahinoor and Youakim, James M. and Creese, Byron and Kumar, Sanjeev and Nuñez, Nicolas and Ryan Darby, R. and Di Vita, Antonella and D'Antonio, Fabrizia and de Lena, Carlo and McGeown, William J. and Ramit, Ravona and Rasmussen, Jill and Bell, Joanne and Wang, Huali and Bruneau, Marie Andrée and Panegyres, Peter K. and Lanctôt, Krista L. and Agüera-Ortiz, Luis and Lyketsos, Constantine and Cummings, Jeffrey and Jeste, Dilip V. and Sano, Mary and Devanand, D. P. and Sweet, Robert A. and Ballard, Clive (2020) Revisiting criteria for psychosis in Alzheimer's disease and related dementias : toward better phenotypic classification and biomarker research. Journal of Alzheimer's Disease : JAD, 73 (3). pp. 1143-1156. ISSN 1875-8908 (

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BACKGROUND: Psychotic symptoms are common in Alzheimer's disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice. OBJECTIVE: To establish research criteria for the diagnosis of psychosis in AD. METHODS: The International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup reviewed existing criteria for psychosis in AD and related dementias. Through a series of in person and on-line meetings, a priority checklist was devised to capture features necessary for current research and clinical needs. PubMed, Medline and other relevant databases were searched for relevant criteria. RESULTS: Consensus identified three sets of criteria suitable for review including those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental Disorders, 5th edition. It was concluded that existing criteria could be augmented by including a more specific differentiation between delusions and hallucinations, address overlap with related conditions (agitation in particular), adding the possibility of symptoms emerging in the preclinical and prodromal phases, and building on developing research in disease biomarkers. CONCLUSION: We propose criteria, developed to improve phenotypic classification of psychosis in AD, and advance the research agenda in the field to improve epidemiological, biomarker, and genetics research in the field. These criteria serve as a complement to the International Psychogeriatric Association criteria for psychosis in neurocognitive disorders.


Fischer, Corinne E., Ismail, Zahinoor, Youakim, James M., Creese, Byron, Kumar, Sanjeev, Nuñez, Nicolas, Ryan Darby, R., Di Vita, Antonella, D'Antonio, Fabrizia, de Lena, Carlo, McGeown, William J. ORCID logoORCID:, Ramit, Ravona, Rasmussen, Jill, Bell, Joanne, Wang, Huali, Bruneau, Marie Andrée, Panegyres, Peter K., Lanctôt, Krista L., Agüera-Ortiz, Luis, Lyketsos, Constantine, Cummings, Jeffrey, Jeste, Dilip V., Sano, Mary, Devanand, D. P., Sweet, Robert A. and Ballard, Clive;