Biocatalytic alkylation cascades: recent advances and future opportunities for late-stage functionalization
McKean, Iain J. W. and Hoskisson, Paul A. and Burley, Glenn A. (2020) Biocatalytic alkylation cascades: recent advances and future opportunities for late-stage functionalization. Chembiochem, 21 (20). pp. 2890-2897. ISSN 1439-4227
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Abstract
This Concept article describes the latest developments in the emerging area of late-stage biocatalytic alkylation. Central to these developments is the ability to efficiently prepare S-adenosyl methionine (SAM) cofactor analogues and couple this with enzymatic alkyl transfer. Recent developments in the enzymatic synthesis of SAM cofactor analogues are summarized first, followed by their application as alkyl transfer agents catalyzed by methyltransferases (MTases). Second, innovative methods to regenerate SAM cofactors by enzymatic cascades is reported. Finally, future opportunities towards establishing a generalized platform for late-stage alkylation are described.
Creators(s): |
McKean, Iain J. W. ![]() ![]() | Item type: | Article |
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ID code: | 72552 |
Keywords: | alkylation, biocatalysis, cascades, regeneration, S-adenosyl methionine, Chemistry, Medicine(all) |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Bionanotechnology |
Depositing user: | Pure Administrator |
Date deposited: | 03 Jun 2020 15:13 |
Last modified: | 05 Mar 2021 04:32 |
URI: | https://strathprints.strath.ac.uk/id/eprint/72552 |
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