Biocatalytic alkylation cascades: recent advances and future opportunities for late-stage functionalization

McKean, Iain J. W. and Hoskisson, Paul A. and Burley, Glenn A. (2020) Biocatalytic alkylation cascades: recent advances and future opportunities for late-stage functionalization. Chembiochem. ISSN 1439-4227

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    Abstract

    This Concept article describes the latest developments in the emerging area of late-stage biocatalytic alkylation. Central to these developments is the ability to efficiently prepare S-adenosyl methionine (SAM) cofactor analogues and couple this with enzymatic alkyl transfer. Recent developments in the enzymatic synthesis of SAM cofactor analogues are summarized first, followed by their application as alkyl transfer agents catalyzed by methyltransferases (MTases). Second, innovative methods to regenerate SAM cofactors by enzymatic cascades is reported. Finally, future opportunities towards establishing a generalized platform for late-stage alkylation are described.

    Creators(s): McKean, Iain J. W. ORCID logoORCID: https://orcid.org/0000-0002-4970-1508, Hoskisson, Paul A. ORCID logoORCID: https://orcid.org/0000-0003-4332-1640 and Burley, Glenn A.;
    Item type:Article
    ID code:72552
    Keywords:alkylation, biocatalysis, cascades, regeneration, S-adenosyl methionine, Chemistry, Medicine(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Technology and Innovation Centre > Bionanotechnology
    Depositing user: Pure Administrator
    Date deposited:03 Jun 2020 15:13
    Last modified:07 Sep 2020 04:38
    URI:https://strathprints.strath.ac.uk/id/eprint/72552
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