Notch3 signalling and vascular remodelling in pulmonary arterial hypertension
Morris, Hannah E. and Neves, Karla B. and Montezano, Augusto C. and MacLean, Margaret R. and Touyz, Rhian M. (2019) Notch3 signalling and vascular remodelling in pulmonary arterial hypertension. Clinical Science, 133 (24). pp. 2481-2498. ISSN 0143-5221 (https://doi.org/10.1042/CS20190835)
Preview |
Text.
Filename: Morris_etal_CS_2019_Notch3_signalling_and_vascular_remodelling_in_pulmonary_arterial_hypertension.pdf
Final Published Version License: ![]() Download (1MB)| Preview |
Abstract
Notch signalling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1-4) regulating diverse cellular processes have been identified. Of these, Notch3 is expressed almost exclusively in vascular smooth muscle cells (VSMCs), where it is critically involved in vascular development and differentiation. Under pathological conditions, Notch3 regulates VSMC switching between the contractile and synthetic phenotypes. Abnormal Notch3 signalling plays an important role in vascular remodelling, a hallmark of several cardiovascular diseases, including pulmonary arterial hypertension (PAH). Because of the importance of Notch3 in VSMC (de)differentiation, Notch3 has been implicated in the pathophysiology of pulmonary vascular remodelling in PAH. Here we review the current literature on the role of Notch in VSMC function with a focus on Notch3 signalling in pulmonary artery VSMCs, and discuss potential implications in pulmonary artery remodelling in PAH.
ORCID iDs
Morris, Hannah E., Neves, Karla B.
-
-
Item type: Article ID code: 71840 Dates: DateEvent23 December 2019Published11 December 2019AcceptedKeywords: notch receptors, pulmonary arteries, signal transduction, vascular smooth muscle cells, Therapeutics. Pharmacology, Pulmonary and Respiratory Medicine Subjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 23 Mar 2020 10:19 Last modified: 24 Jan 2023 02:42 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/71840