Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery

Domingo-Roca, Roger and Saltin, Brian and Windmill, James and Jackson, Joseph and Mulvana, Helen; (2019) Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery. In: 2019 IEEE International Ultrasonics Symposium, IUS 2019. IEEE International Ultrasonics Symposium, IUS . IEEE Computer Society Press, GBR, pp. 2390-2393. ISBN 9781728145969

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    Abstract

    The ability to undertake controlled and accurate investigation of the complex features that determine microvasculature-fluid systems is essential in our progress towards successful clinical exploitation of ultrasound mediated targeted drug delivery (UmTDD). We present an engineered platform to enable accurate understanding of the microvascular flow characteristics capable of influencing UmTDD. We develop novel 3D-printed flow phantoms, accurately replicating real microvascular structures, and a new approach to investigating UmTDD phenomena that places microbubble-microvessel interactions at the heart of the problem. Our aim is to establish a robust, lab-based platform for controlled and systematic investigation of microvessel architectures as key determinants in UmTDD efficiency.