Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery

Domingo-Roca, Roger and Saltin, Brian and Windmill, James and Jackson, Joseph and Mulvana, Helen; (2019) Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery. In: 2019 IEEE International Ultrasonics Symposium, IUS 2019. IEEE International Ultrasonics Symposium, IUS . IEEE Computer Society Press, GBR, pp. 2390-2393. ISBN 9781728145969

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    Abstract

    The ability to undertake controlled and accurate investigation of the complex features that determine microvasculature-fluid systems is essential in our progress towards successful clinical exploitation of ultrasound mediated targeted drug delivery (UmTDD). We present an engineered platform to enable accurate understanding of the microvascular flow characteristics capable of influencing UmTDD. We develop novel 3D-printed flow phantoms, accurately replicating real microvascular structures, and a new approach to investigating UmTDD phenomena that places microbubble-microvessel interactions at the heart of the problem. Our aim is to establish a robust, lab-based platform for controlled and systematic investigation of microvessel architectures as key determinants in UmTDD efficiency.

    ORCID iDs

    Domingo-Roca, Roger ORCID logoORCID: https://orcid.org/0000-0001-6080-0083, Saltin, Brian ORCID logoORCID: https://orcid.org/0000-0001-6668-962X, Windmill, James ORCID logoORCID: https://orcid.org/0000-0003-4878-349X, Jackson, Joseph and Mulvana, Helen ORCID logoORCID: https://orcid.org/0000-0002-5058-0299;
    • Item type:Book Section
      ID code:71713
      Dates:
      Date
      Event
      6 December 2019
      Published
      6 October 2019
      Accepted
      Notes:© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
      Keywords:3D-Printing, microCT, microvasculature, phantom, ultrasound-mediated targeted drug delivery, Bioengineering, Acoustics and Ultrasonics
      Subjects:Technology > Engineering (General). Civil engineering (General) > Bioengineering
      Department:Faculty of Engineering > Electronic and Electrical Engineering
      Depositing user: Pure Administrator
      Date deposited:06 Mar 2020 11:30
      Last modified:03 Mar 2021 02:20
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/71713
    CORE (COnnecting REpositories)