Two-dimensional infrared spectroscopy : an emerging analytical tool?

Fritzsch, Robby and Hume, Samantha and Minnes, Lucy and Baker, Matthew J. and Burley, Glenn A. and Hunt, Neil T. (2020) Two-dimensional infrared spectroscopy : an emerging analytical tool? Analyst, 145 (6). pp. 2014-2024. ISSN 0003-2654

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    Ultrafast two-dimensional infrared (2D-IR) spectroscopy has provided valuable insights into biomolecular structure and dynamics, but recent progress in laser technology and data analysis methods have demonstrated the potential for high throughput 2D-IR measurements and analytical applications. Using 2D-IR as an analytical tool requires a different approach to data collection and analysis compared to pure research applications however and, in this review, we highlight progress towards usage of 2D-IR spectroscopy in areas relevant to biomedical, pharmaceutical and analytical molecular science. We summarise the technical and methodological advances made to date and discuss the challenges that still face 2D-IR spectroscopy as it attempts to transition from the state-of-the-art laser laboratory to the standard suite of analytical tools.