Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents

Hoskins, Clare and Curtis, Anthony D.M. (2015) Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents. Journal of Nanomedicine Research, 2 (3). 00028. (https://doi.org/10.15406/jnmr.2015.02.00028)

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Abstract

Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

  • Item type:Article
    ID code:70607
    Dates:
    Date
    Event
    20 April 2015
    Published
    19 April 2015
    Accepted
    Keywords:calix[n]arene, drug solubilization, calix[4]resorcinarene, bioavailability, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all), Chemistry(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:21 Nov 2019 12:49
    Last modified:29 May 2023 01:23
    URI:https://strathprints.strath.ac.uk/id/eprint/70607
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