Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

Bole, Leonie J. and Davin, Laia and Kennedy, Alan R. and McLellan, Ross and Hevia, Eva (2019) Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes. Chemical Communications, 55 (30). pp. 4339-4342. ISSN 1359-7345

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Official URL: https://doi.org/10.1039/C9CC01670H

Abstract

A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.

Author(s):	Bole, Leonie J., Davin, Laia ORCID: https://orcid.org/0000-0002-7927-4930, Kennedy, Alan R. ORCID: https://orcid.org/0000-0003-3652-6015, McLellan, Ross ORCID: https://orcid.org/0000-0001-9700-0258 and Hevia, Eva ORCID: https://orcid.org/0000-0002-3998-7506
Item type:	Article
ID code:	70542
Keywords:	Fluorinated aromatic molecules, medicinal chemistry, Magnesium-mediated arylation, Physical and theoretical chemistry, Physical and Theoretical Chemistry
Subjects:	Science > Chemistry > Physical and theoretical chemistry
Department:	Faculty of Science > Pure and Applied Chemistry
Depositing user:	Pure Administrator
Date deposited:	15 Nov 2019 15:59
Last modified:	11 Feb 2020 04:58
URI:	https://strathprints.strath.ac.uk/id/eprint/70542
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