Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

Bole, Leonie J. and Davin, Laia and Kennedy, Alan R. and McLellan, Ross and Hevia, Eva (2019) Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes. Chemical Communications, 55 (30). pp. 4339-4342. ISSN 1359-7345

[thumbnail of Bole-etal-CS-2019-Magnesium-mediated-arylation-of-amines-via-C-F-bond-activation-of-fluoroarenes]
Preview
 Text (Bole-etal-CS-2019-Magnesium-mediated-arylation-of-amines-via-C-F-bond-activation-of-fluoroarenes)
Bole_etal_CS_2019_Magnesium_mediated_arylation_of_amines_via_C_F_bond_activation_of_fluoroarenes.pdf
Accepted Author Manuscript
Download (953kB)| Preview

    Abstract

    A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.

    ORCID iDs

    Bole, Leonie J., Davin, Laia ORCID logoORCID: https://orcid.org/0000-0002-7927-4930, Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, McLellan, Ross ORCID logoORCID: https://orcid.org/0000-0001-9700-0258 and Hevia, Eva ORCID logoORCID: https://orcid.org/0000-0002-3998-7506;
    • Item type:Article
      ID code:70542
      Dates:
      Date
      Event
      13 March 2019
      Published
      12 March 2019
      Accepted
      Keywords:Fluorinated aromatic molecules, medicinal chemistry, Magnesium-mediated arylation, Physical and theoretical chemistry, Physical and Theoretical Chemistry
      Subjects:Science > Chemistry > Physical and theoretical chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:15 Nov 2019 15:59
      Last modified:23 Sep 2021 07:32
      URI:https://strathprints.strath.ac.uk/id/eprint/70542
    CORE (COnnecting REpositories)