Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes
Bole, Leonie J. and Davin, Laia and Kennedy, Alan R. and McLellan, Ross and Hevia, Eva (2019) Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes. Chemical Communications, 55 (30). pp. 4339-4342. ISSN 1359-7345
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Official URL: https://doi.org/10.1039/C9CC01670H
Abstract
A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.
Creators(s): |
Bole, Leonie J., Davin, Laia ![]() ![]() ![]() ![]() | Item type: | Article |
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ID code: | 70542 |
Keywords: | Fluorinated aromatic molecules, medicinal chemistry, Magnesium-mediated arylation, Physical and theoretical chemistry, Physical and Theoretical Chemistry |
Subjects: | Science > Chemistry > Physical and theoretical chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 15 Nov 2019 15:59 |
Last modified: | 01 Feb 2021 02:25 |
URI: | https://strathprints.strath.ac.uk/id/eprint/70542 |
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