Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

Bole, Leonie J. and Davin, Laia and Kennedy, Alan R. and McLellan, Ross and Hevia, Eva (2019) Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes. Chemical Communications, 55 (30). pp. 4339-4342. ISSN 1359-7345

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    Abstract

    A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.

    Creators(s): Bole, Leonie J., Davin, Laia ORCID logoORCID: https://orcid.org/0000-0002-7927-4930, Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, McLellan, Ross ORCID logoORCID: https://orcid.org/0000-0001-9700-0258 and Hevia, Eva ORCID logoORCID: https://orcid.org/0000-0002-3998-7506;
    Item type:Article
    ID code:70542
    Keywords:Fluorinated aromatic molecules, medicinal chemistry, Magnesium-mediated arylation, Physical and theoretical chemistry, Physical and Theoretical Chemistry
    Subjects:Science > Chemistry > Physical and theoretical chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:15 Nov 2019 15:59
    Last modified:27 Mar 2020 02:12
    URI:https://strathprints.strath.ac.uk/id/eprint/70542
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