Thermally triggered theranostics for pancreatic cancer therapy
Malekigorji, Maryam and Alfahad, Mohanad and Kong Thoo Lin, Paul and Jones, Stephanie and Curtis, Anthony and Hoskins, Clare (2017) Thermally triggered theranostics for pancreatic cancer therapy. Nanoscale, 9 (34). 12735–12745. ISSN 2040-3372 (https://doi.org/10.1039/C7NR02751F)
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Abstract
Hybrid iron oxide–gold nanoparticles (HNPs) show the ability to bind drugs onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide a specific and effective method for pancreatic cancer treatment. Here we used a novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) showed the ability to load drugs onto their surface (3 : 1 : 0.25, drug : Fe : Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved. A 12-fold reduction in IC50 after 24 h in vitro and a 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment were achieved with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapeutic strategies.
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Item type: Article ID code: 70528 Dates: DateEvent3 August 2017Published31 July 2017AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 14 Nov 2019 16:31 Last modified: 20 Aug 2024 12:24 URI: https://strathprints.strath.ac.uk/id/eprint/70528