Hydrogen atom transfer‐mediated cyclisations of nitriles
Turner, Oliver J. and Murphy, John A. and Hirst, David J. and Talbot, Eric P. A. (2018) Hydrogen atom transfer‐mediated cyclisations of nitriles. Chemistry - A European Journal, 24 (70). 18658–18662. ISSN 0947-6539
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Official URL: https://doi.org/10.1002/chem.201805236
Abstract
Hydrogen atom transfer‐mediated intramolecular C−C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This introduces a new strategic bond disconnection for ring‐closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.
Creators(s): | Turner, Oliver J., Murphy, John A., Hirst, David J. and Talbot, Eric P. A.; | Item type: | Article |
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ID code: | 70160 |
Notes: | This is the peer reviewed version of the following article:Turner, O. J., Murphy, J. A., Hirst, D. J., & Talbot, E. P. A. (2018). Hydrogen atom transfer‐mediated cyclisations of nitriles. Chemistry - A European Journal, 24(70), 18658–18662., which has been published in final form at https://doi.org/10.1002/chem.201805236. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | alkenes, nitriles, PhSiH3, catalytic Fe(acac)3, ring‐closing reactions, iron‐mediated HAT reactions, Physical and theoretical chemistry, Physical and Theoretical Chemistry |
Subjects: | Science > Chemistry > Physical and theoretical chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 17 Oct 2019 11:12 |
Last modified: | 26 Feb 2021 05:27 |
URI: | https://strathprints.strath.ac.uk/id/eprint/70160 |
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