Hydrogen atom transfer‐mediated cyclisations of nitriles

Turner, Oliver J. and Murphy, John A. and Hirst, David J. and Talbot, Eric P. A. (2018) Hydrogen atom transfer‐mediated cyclisations of nitriles. Chemistry - A European Journal, 24 (70). 18658–18662. ISSN 0947-6539

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    Abstract

    Hydrogen atom transfer‐mediated intramolecular C−C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This introduces a new strategic bond disconnection for ring‐closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.

    • Item type:Article
      ID code:70160
      Dates:
      Date
      Event
      12 December 2018
      Published
      20 October 2018
      Published Online
      18 October 2018
      Accepted
      Notes:This is the peer reviewed version of the following article:Turner, O. J., Murphy, J. A., Hirst, D. J., & Talbot, E. P. A. (2018). Hydrogen atom transfer‐mediated cyclisations of nitriles. Chemistry - A European Journal, 24(70), 18658–18662., which has been published in final form at https://doi.org/10.1002/chem.201805236. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
      Keywords:alkenes, nitriles, PhSiH3, catalytic Fe(acac)3, ring‐closing reactions, iron‐mediated HAT reactions, Physical and theoretical chemistry, Physical and Theoretical Chemistry
      Subjects:Science > Chemistry > Physical and theoretical chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:17 Oct 2019 11:12
      Last modified:02 Jul 2021 02:55
      URI:https://strathprints.strath.ac.uk/id/eprint/70160
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