Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry
Denver, Nina and Khan, Shazia and Stasinopoulos, Ioannis and Church, Colin and Homer, Natalie Z.M. and MacLean, Margaret R. and Andrew, Ruth (2019) Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry. Data in Brief, 23. 103740. ISSN 2352-3409 (https://doi.org/10.1016/j.dib.2019.103740)
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Abstract
Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature. Derivatization to methyl piperazine analogues has been reported for a panel of 9 estrogens in, “Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry” (Denver et al., 2019). Data show alteration of the base catalyst in this method was required to allow detection of catechol estrogens to low levels. Data also highlight the challenges faced in chromatographic separation of isomers and isotopologues, which were partially overcome by employing an extended column length and reduced oven temperature. In addition, data analysis displayed significant matrix effects during quantitation in plasma, following solid-phase extraction, despite efficient recoveries.
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Item type: Article ID code: 70141 Dates: DateEvent30 April 2019Published8 March 2019Published Online1 February 2019AcceptedKeywords: catechol estrogen, liquid chromatography, mass spectrometry, metabolites, Pharmacy and materia medica, General, Pharmacology, Toxicology and Pharmaceutics(all) Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Humanities and Social Sciences (HaSS) > School of Psychological Science and HealthDepositing user: Pure Administrator Date deposited: 16 Oct 2019 11:42 Last modified: 26 Sep 2021 01:58 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/70141