Paracetamol habit modification by impurities

Urwin, Stephanie and Martin, Alan and Ter Horst, Joop (2019) Paracetamol habit modification by impurities. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

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    The presence of impurities during crystallisation can affect final crystal attributes other than chemical purity. For example,metacetamol, a regioisomer of paracetamol, has been reported to modify the morphology of the API, leading to theisolation of columnar crystals in place of crystals with an equant habit. Small scale recrystallisation of pure paracetamolfrom 2-propanol was found here to produce small, relatively equant crystals.