The role of neuronal NLRP1 inflammasome in Alzheimer's disease : bringing neurons into the neuroinflammation game
Yap, Jeremy Kean Yi and Pickard, Benjamin Simon and Chan, Elaine Wan Ling and Gan, Sook Yee (2019) The role of neuronal NLRP1 inflammasome in Alzheimer's disease : bringing neurons into the neuroinflammation game. Molecular Neurobiology, 56 (11). pp. 7741-7753. ISSN 1559-1182 (https://doi.org/10.1007/s12035-019-1638-7)
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Abstract
The innate immune system and inflammatory response in the brain have critical impacts on the pathogenesis of many neurodegenerative diseases including Alzheimer’s disease (AD). In the central nervous system (CNS), the innate immune response is primarily mediated by microglia. However, non-glial cells such as neurons could also partake in inflammatory response independently through inflammasome signalling. The NLR family pyrin domain-containing 1 (NLRP1) inflammasome in the CNS is primarily expressed by pyramidal neurons and oligodendrocytes. NLRP1 is activated in response to amyloid-β (Aβ) aggregates, and its activation subsequently cleaves caspase-1 into its active subunits. The activated caspase-1 proteolytically processes interleukin-1β (IL-1β) and interleukin-18 (IL-18) into maturation whilst co-ordinately triggers caspase-6 which is responsible for apoptosis and axonal degeneration. In addition, caspase-1 activation induces pyroptosis, an inflammatory form of programmed cell death. Studies in murine AD models indicate that the Nlrp1 inflammasome is indeed upregulated in AD and neuronal death is observed leading to cognitive decline. However, the mechanism of NLRP1 inflammasome activation in AD is particularly elusive, given its structural and functional complexities. In this review, we examine the implications of the human NLRP1 inflammasome and its signalling pathways in driving neuroinflammation in AD.
ORCID iDs
Yap, Jeremy Kean Yi, Pickard, Benjamin Simon ORCID: https://orcid.org/0000-0002-2374-6329, Chan, Elaine Wan Ling and Gan, Sook Yee;-
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Item type: Article ID code: 69272 Dates: DateEvent1 November 2019Published20 May 2019Published Online6 May 2019AcceptedSubjects: Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry
Medicine > Pharmacy and materia medicaDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 09 Aug 2019 13:22 Last modified: 11 Sep 2024 00:47 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/69272