Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Lin, Hungyen and Pei, Chunlei and Markl, Daniel and Shen, Yaochun and Elliott, James A. and Axel Zeitler, J. (2018) Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. IET Microwaves, Antennas and Propagation, 12 (11). pp. 1775-1779. ISSN 1751-8725

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    Abstract

    In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.

    Author(s):Lin, Hungyen, Pei, Chunlei, Markl, Daniel ORCID logoORCID: https://orcid.org/0000-0003-0411-733X, Shen, Yaochun, Elliott, James A. and Axel Zeitler, J.
    Item type:Article
    ID code:68882
    Keywords:optical coherence tomography, OCT, pharmaceutical film coatings, tablet mixing, tablet coating, Chemical engineering, Therapeutics. Pharmacology, Chemical Engineering (miscellaneous), Pharmaceutical Science
    Subjects:Technology > Chemical engineering
    Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:17 Jul 2019 10:58
    Last modified:09 Aug 2019 03:17
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/68882
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