The use of probiotics as supplementary therapy in the treatment of patients with asthma : a pilot study and implications

Moura, Jonatas Christian Vieira and Moura, Isabel cristina Gomes and Gaspar, Guilherme Rache and Mendes, Guilherme Matos Serretti and Faria, Bernardo Almeida Vial and Jentzsch, Nulma Souto and Passos, Maria do Carmo Friche and Kurdi, Amanj and Godman, Brian and Almeida, Alessandra Maciel (2019) The use of probiotics as supplementary therapy in the treatment of patients with asthma : a pilot study and implications. Clinics. ISSN 1807-5932 (In Press)

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    Abstract

    Objectives: Evaluate the use of probiotic as additional therapy in the treatment of children and adolescents with asthma in Belo Horizonte, MG-Brazil. Methods: A pilot longitudinal, experimental and non-randomized study with 30 patients from six to 17 years old from Belo Horizonte. In the basal appointment, all patients received beclomethasone and one group received a probiotic containing Lactobacillus reuteri (n=14). The patients were reassessed after 60 days at least, being submitted to the Asthma Control Test, spirometry and report the symptoms associated to asthma. Results: It was observed predominance of male sex (56.7%) and mean age of 10.6 years. The groups using probiotic did not differ regarding sex, age or atopy. In the longitudinal evaluation, it was observed an increase of the Asthma Control Test in probiotic group, as well as the reduction of the number of symptoms. There was an increase in the peak expiratory flow among those who used or not probiotic. Conclusions: This pilot study raise the hypothesis that the administration of probiotic as a supplementary therapy for the treatment of children and adolescents with asthma seems to have improved the patients’ clinical condition. Further studies are needed to confirm the efficacy of probiotics in the asthma treatment.