Concerted nucleophilic aromatic substitution reactions

Rohrbach, Simon and Smith, Andrew J. and Pang, Jia Hao and Poole, Darren L. and Tuttle, Tell and Chiba, Shunsuke and Murphy, John A. (2019) Concerted nucleophilic aromatic substitution reactions. Angewandte Chemie International Edition, 58 (46). pp. 16368-16388. ISSN 1433-7851

[thumbnail of Rohrbach-etal-ACIE-2019-Concerted-nucleophilic-aromatic-substitution-reactions]
Preview
 Text (Rohrbach-etal-ACIE-2019-Concerted-nucleophilic-aromatic-substitution-reactions)
Rohrbach_etal_ACIE_2019_Concerted_nucleophilic_aromatic_substitution_reactions.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (3MB)| Preview

    Abstract

    Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) rather than classical, two-step, SNAr mechanisms. Whereas traditional SNAr reactions require substantial activation of the aromatic ring by electron-withdrawing substituents, such activating groups are not mandatory in the concerted pathways. At this crucial stage of growth in understanding of these reactions, our aim is to review the current state of knowledge on cSNAr reactions. [The review includes many types of substrates and nucleophiles; it specifically excludes transition metal-related processes that might involve concerted substitutions on arenes].

    ORCID iDs

    Rohrbach, Simon, Smith, Andrew J. ORCID logoORCID: https://orcid.org/0000-0001-7848-076X, Pang, Jia Hao, Poole, Darren L., Tuttle, Tell, Chiba, Shunsuke and Murphy, John A.;
    • Item type:Article
      ID code:67652
      Dates:
      Date
      Event
      11 November 2019
      Published
      16 April 2019
      Published Online
      12 April 2019
      Accepted
      Keywords:nucleophilic aromatic substitutions, substitution reactions, electron transfer, Chemistry, Chemistry(all)
      Subjects:Science > Chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:30 Apr 2019 13:53
      Last modified:16 Oct 2021 00:35
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/67652
    CORE (COnnecting REpositories)