In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture
McGinty, Sean and Hyndman, Lauren and Mottram, Nigel and McKee, Sean and Webb, Steven; Nithiarasu, Perumal and Robertson, Anne M., eds. (2017) In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. In: CMBE17. Zeta Computational Resources Ltd., USA, pp. 1174-1177. ISBN 9780956291448
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Abstract
We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.
Creators(s): |
McGinty, Sean, Hyndman, Lauren, Mottram, Nigel ![]() | Item type: | Book Section |
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ID code: | 67549 |
Keywords: | cell culture systems, bioreactors, fluid dynamics, drug toxicity testing, Bioengineering, Mathematics, Biomedical Engineering, Mathematics(all) |
Subjects: | Technology > Engineering (General). Civil engineering (General) > Bioengineering Science > Mathematics |
Department: | Faculty of Science > Mathematics and Statistics |
Depositing user: | Pure Administrator |
Date deposited: | 11 Apr 2019 11:41 |
Last modified: | 31 Dec 2020 02:43 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/67549 |
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