In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

McGinty, Sean and Hyndman, Lauren and Mottram, Nigel and McKee, Sean and Webb, Steven; Nithiarasu, Perumal and Robertson, Anne M., eds. (2017) In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. In: CMBE17. Zeta Computational Resources Ltd., USA, pp. 1174-1177. ISBN 9780956291448

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Abstract

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

Creators(s):	McGinty, Sean, Hyndman, Lauren, Mottram, Nigel ORCID: https://orcid.org/0000-0002-7265-0059, McKee, Sean and Webb, Steven; Nithiarasu, Perumal and Robertson, Anne M.
Item type:	Book Section
ID code:	67549
Keywords:	cell culture systems, bioreactors, fluid dynamics, drug toxicity testing, Bioengineering, Mathematics, Biomedical Engineering, Mathematics(all)
Subjects:	Technology > Engineering (General). Civil engineering (General) > Bioengineering Science > Mathematics
Department:	Faculty of Science > Mathematics and Statistics
Depositing user:	Pure Administrator
Date deposited:	11 Apr 2019 11:41
Last modified:	31 Dec 2020 02:43
Related URLs:	Journal or Publication Related item
URI:	https://strathprints.strath.ac.uk/id/eprint/67549
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